10th Annual 3Rs Symposium: The 3Rs in Action!

The following videos are selected presentations focusing on 3Rs (replacement, reduction, and refinement of animal use) methods to improve laboratory animal welfare while maintaining or improving scientific results. Topics include liver-chip technologies, environmental health monitoring, refinement and enrichment strategies, regulatory insights into the 3Rs among other topics. The 2023 Symposium playlist on The 3Rs in Action! can be viewed on YouTube or as individual videos below.

The 2023 Symposium was held virtually and co-hosted by:

USDA, NAL, Animal Welfare Information Center (AWIC)
NIH Office of Laboratory Animal Welfare (OLAW)
Johns Hopkins Department of Molecular and Comparative Pathobiology
Johns Hopkins Center for Alternatives to Animal Testing (CAAT)

Table of content

Organizers’ Welcome: 10th Anniversary

Speakers: Patricia Brown, NIH, OLAW; Eric Hutchinson, Johns Hopkins Department of Molecular and Comparative Pathobiology; Joanne Zurlo, Kathrin Herrmann, Johns Hopkins CAAT; and Kristina Adams, USDA, AWIC

Keynote Orphan 3Rs

Speaker: Thomas Hartung, Johns Hopkins Center for Alternatives to Animal Testing (CAAT)

Welfare of Primates in Laboratories: Opportunities for Refinement

Speaker: Hannah Buchanan-Smith, University of Stirling

Arguments Against Nonhuman Primate Research, & Why Replacement Must Be the Focus

Speaker: Jarrod Bailey, Animal Free Research U.K.

How Do We Effectuate the 3Rs?

Speaker: Merel Ritskes-Hoitinga, Utrecht University

Performance Assessment of a Liver-Chip for Prediction of Drug-Induced Liver Injury and Incorporation Within Laboratory Workflows

Speaker: Lorna Ewart, Emulate

Replacing Sentinel Rodents With Environmental Health Monitoring

Speaker: Megan Lafollette, 3Rs Collaborative, Inc.

Practical Implementation of Enrichment for Laboratory Zebrafish

Speaker: Chloe Stevens, Royal Society for the Prevention of Cruelty to Animals (RSPCA)

Refinements in Cage Bedding for the Improvement of Mouse Welfare and Husbandry Efficiency

Speaker: Brooke Pallas, University of Michigan

Practical Application of Cumulative Endpoints

Speaker: Pat Turner, Charles River Laboratories

Pathways to Continuous Improvement

Speaker: Steve Niemi, Boston University

Panel Discussion with AAALAC/FDA/NIH/USDA on the 3Rs

Speakers: Gary Borkowski, AAALAC International; Suzanne Fitzpatrick, FDA; Nicolette Petervary, NIH OLAW; Gwen Maginnis, USDA APHIS AC

These presentations are being hosted by the Animal Welfare Information Center, a service of The National Agricultural Library. Staff did not edit or otherwise modify the original materials. The views expressed in the presentations do not necessarily reflect the policies of the National Agricultural Library or the United States Department of Agriculture.