An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Research Publications (Food Safety)

This page tracks research articles published in national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. Research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies (requires login) and FDA Grant Funding Agencies (requires login) are also tracked in Scopus.

Displaying 126 - 150 of 2013

  1. Cocoa‐associated filamentous fungi for the biocontrol of aflatoxigenic Aspergillus flavus

    • Journal of Basic Microbiology
    • Abstract Aflatoxin and other mycotoxin contamination are major threats to global food security and present an urgent need to secure the global food crop against spoilage by mycotoxigenic fungi. Cocoa material is noted for naturally low aflatoxin contamination. This study was designed to assess the potential for harnessing cocoa‐associated filamentous fungi for the biocontrol of aflatoxigenic Aspergillus flavus.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  2. Aflatoxin levels and Aspergillus species in maize in the Province of Isabela, Philippines

    • Journal of Phytopathology
    • Abstract The province of Isabela is the top maize producer in the Philippines. The intensive cultivation and the tropical climate in the region may favour fungal growth and aflatoxin contamination in maize grains. Thus, the study aimed to determine the occurrence of aflatoxin and mycotoxigenic Aspergillus species in maize varieties in this region.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  3. Detoxifying mycotoxins and antifungal properties of two rumen‐derived Enterococcus species in artificially contaminated corn silages

    • Journal of the Science of Food and Agriculture
    • Abstract BACKGROUND Mycotoxins contamination in food and feed has emerged as an issue of serious concern because they pose serious health risks to both humans and livestock. The study aimed to evaluate the effects of two rumen‐derived Enterococcus spp. on fermentation and hygienic quality of artificially contaminated corn silages.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  4. Preparation of size-tunable Fe3O4 magnetic nanoporous carbon composites by MOF pyrolysis regulation for magnetic resonance sensing of aflatoxin B1 with excellent anti-matrix effect

    • Food Chemistry
    • Magnetic nanoporous materials represent a new emerging category of magnetic materials for construction of magnetic resonance sensors. In this study, we adopted the metal–organic framework materials, MIL-101(Fe), as the precursor to prepare series nanoporous-carbon-Fe3O4 (NPC-Fe3O4) composites.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  5. In Vivo Genotoxicity and Toxicity Assessment of Sterigmatocystin Individually and in Mixture with Aflatoxin B1

    • Toxins
    • Mycotoxins are natural food and feed contaminants produced by several molds. The primary mode of exposure in humans and animals is through mixtures. Aflatoxin B1 (AFB1) and sterigmatocystin (STER) are structurally related mycotoxins that share the same biosynthetic route. Few in vivo genotoxicity assays have been performed with STER.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  6. Survey and toxigenic abilities of Aspergillus, Fusarium, and Alternaria fungi from wheat and paddy grains in Shanghai, China

    • Frontiers in Plant Science
    • A systematic study was carried out on 638 wheat and paddy grains (including fresh and stored samples) collected in 2021 from Shanghai, China, to identify the major mycobiota and their toxigenic abilities. A total of 349 fungi, namely, 252 Fusarium, 53 Aspergillus, and 44 Alternaria, were characterized by morphological and molecular identification.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  7. Research Progress Related to Aflatoxin Contamination and Prevention and Control of Soils

    • Toxins
    • Aflatoxins are potent carcinogenic compounds, mainly produced by fungi species of the genus Aspergillus in the soil. Because of their stability, they are difficult to remove completely, even under extreme conditions. Aflatoxin contamination is one of the main causes of safety in peanuts, maize, wheat and other agricultural products. Aflatoxin contamination originates from the soil.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  8. Assessment of early harvest in the prevention of aflatoxins in peanuts during drought stress conditions

    • International Journal of Food Microbiology
    • The present study aimed to evaluate the effectiveness of early harvest in preventing aflatoxins in peanuts under drought-stress conditions. A field experiment was conducted on the 2018–2019 and 2019–2020 growing seasons in a greenhouse with an irrigation system to induce three drought stress conditions: no stress, mild, and severe stress. In addition, three harvest dates were proposed: two weeks earlier, one week earlier, and ideal harvest time.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  9. Rapid Detection of Single- and Co-contaminant Aflatoxins and Fumonisins in Ground Maize using Hyperspectral Imaging Techniques

    • Toxins
    • Aflatoxins and fumonisins, commonly found in maize and maize-derived products, frequently co-occur and can cause dangerous illness in humans and animals if ingested in large amounts. Efforts are being made to develop suitable analytical methods for screening that can rapidly detect mycotoxins in order to prevent illness through early detection.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  10. Sampling locations and processing methods shape fungi microbiome on the surface of edible and medicinal Arecae semen

    • Frontiers in Microbiology
    • Introduction Arecae semen, which is derived from the dried ripe seed of Areca catechu L., has been commonly used as one of the major traditional Chinese medicines (TCMs). Three types of crude herbal preparations, namely, raw Arecae semen (AS), Arecae semen tostum (SAS), and Arecae semen carbonisata (FAS), are available for different clinical applications in TCMs.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  11. Comprehensive meta-analysis of QTL and gene expression studies identify candidate genes associated with Aspergillus flavus resistance in maize

    • Frontiers in Plant Science
    • Aflatoxin (AF) contamination, caused by Aspergillus flavus, compromises the food safety and marketability of commodities, such as maize, cotton, peanuts, and tree nuts. Multigenic inheritance of AF resistance impedes conventional introgression of resistance traits into high-yielding commercial maize varieties. Several AF resistance-associated quantitative trait loci (QTLs) and markers have been reported from multiple biparental mapping and genome-wide association studies (GWAS) in maize.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  12. Aflatoxin B1 impairs porcine oocyte quality via disturbing intracellular membrane system and ATP production

    • Ecotoxicology and Environmental Safety
    • Aflatoxin is the most common type of mycotoxins in contaminated corn, peanuts and rice, which affects the livestock and ultimately endangers human health.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  13. Characterization of Particle-Size-Based Homogeneity and Mycotoxin Distribution Using Laser Diffraction Particle Size Analysis

    • Toxins
    • Sample homogeneity dictates whether analyzing a test portion of an entire sample can provide representative information about incurred mycotoxins. In this study, we evaluated particle-size-distribution-based homogeneity of laboratory mycotoxin samples using laser diffraction particle size analysis and International Organization for Standardization (ISO) Guide 35: 2017.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  14. Development of deep eutectic solvent–based microwave‐assisted extraction combined with temperature controlled ionic liquid–based liquid phase microextraction for extraction of aflatoxins from cheese samples

    • Journal of Separation Science
    • Journal of Separation Science, EarlyView. In this study, for the first time, a deep eutectic solvent-based microwave-assisted extraction was combined with ionic liquid–based temperature controlled liquid phase microextraction for the extraction of several aflatoxins from cheese samples.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  15. Occurrence and Exposure Assessment of Major Mycotoxins in Foodstuffs from Algeria

    • Toxins
    • Cereal-based products, nuts and dried fruits are staple foods for the Algerian population. However, these foodstuffs may be sources of harmful mycotoxins, with negative impacts on human health.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  16. Aflatoxin B1 Induces Inflammatory Liver Injury via Gut Microbiota in Mice

    • Journal of Agricultural and Food Chemistry
    • Aflatoxin B1 (AFB1), a potent food-borne hepatocarcinogen, is the most toxic aflatoxin that induces liver injury in humans and animals. Species-specific sensitivities of aflatoxins cannot be fully explained by differences in the metabolism of AFB1 between animal species. The gut microbiota are critical in inflammatory liver injury, but it remains to reveal the role of gut microbiota in AFB1-induced liver injury. Here, mice were gavaged with AFB1 for 28 days.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  17. Determination of Aflatoxins B1, B2, G1, and G2 and Ochratoxin A in Dry Fermented Sausages Using a Dilute and Shoot Method and LC–MS/MS

    • Food Analytical Methods
    • The presence of mycotoxins in meat and meat products can result from contaminated feed carry-over, from contamination with toxigenic molds during processing and storage, and from contaminated spices and ingredients. The occurrence of mycotoxins in dry fermented sausage is described worldwide; however, scarce information is available for Brazilian products.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  18. Simultaneous analysis of mildew degree and aflatoxin B1 of wheat by a multi-task deep learning strategy based on microwave detection technology

    • LWT
    • This study proposes a novel qualitative and quantitative analysis method for wheat mildew degree and aflatoxin B1 (AFB1) by microwave detection technology combined with multi-task learning strategy. The team developed a miniaturized microwave detection device with double heterodyne mixing structure, and used this device to obtain the transmission indexes (amplitude and phase) of moldy wheat samples.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  19. Disease burden contributed by dietary exposure to aflatoxins in a mountainous city in Southwest China

    • Frontiers in Microbiology
    • Introduction

      Aflatoxins (AFT) identified as a Group 1 human carcinogen naturally contaminate various types of food and could increase the risk of hepatocellular carcinoma (HCC) through dietary intake. Chongqing municipality is located in Southwest China with subtropical monsoon climate which is conducive to AFT contamination in crops. However, the burden of HCC caused by the dietary exposure of the population in Chongqing to AFT has not been quantified.

      Methods

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  20. Simultaneous removal of aflatoxin B1 and zearalenone in vegetable oils by hierarchical fungal mycelia@graphene oxide@Fe3O4 adsorbent

    • Food Chemistry
    • Physical adsorbents for detoxification are widely used in vegetable oil industry. So far, the high-efficiency and low-cost adsorbents have not been well explored. Here, a hierarchical fungal mycelia@graphene oxide@Fe3O4 (FM@GO@Fe3O4) was fabricated as an efficient adsorbent for simultaneous removal of aflatoxin B1 (AFB1) and zearalenone (ZEN). The morphological, functional and structural characteristics of the prepared adsorbents were systematic investigated.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  21. Efficacy of Feed Additive Containing Bentonite and Enzymatically Hydrolyzed Yeast on Intestinal Health and Growth of Newly Weaned Pigs under Chronic Dietary Challenges of Fumonisin and Aflatoxin

    • Toxins
    • This study aimed to investigate the efficacy of a feed additive containing bentonite and enzymatically hydrolyzed yeast on the intestinal health and growth of newly weaned pigs under chronic dietary exposure to fumonisin and aflatoxin.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  22. Fit-For-Purpose Method Development to Determine Co-Occurring Multiclass Mycotoxins in Apple and Apple Puree Samples

    • Food Analytical Methods
    • Due to the impact of the climate change on mycotoxins production and their occurrence in foods, it is important to consider the potential accumulation of unexpected mycotoxins in matrices susceptible to be contaminated such as apples. In this regard, a fit-for-purpose LC–MS/MS method to determine co-occurring mycotoxins in apple purees has been proposed, considering the fungal profile isolated from stored apple fruits.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  23. Transcriptomic and Metabolomic Analyses of the Response of Resistant Peanut Seeds to Aspergillus flavus Infection

    • Toxins
    • Peanut seeds are susceptible to Aspergillus flavus infection, which has a severe impact on the peanut industry and human health. However, the molecular mechanism underlying this defense remains poorly understood. The aim of this study was to analyze the changes in differentially expressed genes (DEGs) and differential metabolites during A. flavus infection between Zhonghua 6 and Yuanza 9102 by transcriptomic and metabolomic analysis.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  24. Response surface model to illustrate the benefits of tryptophan, melatonin, and N,N-dimethylglycine in quail chicks exposed to aflatoxin B1

    • Poultry Science
    • A dose-response assay in a central composite design platform was conducted to investigate the responses (performance, immunity, and meat quality) of quail chicks to dietary tryptophan (Trp), melatonin (MEL), and N,N-dimethylglycine (DMG) exposed to aflatoxin B1&nbsp

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  25. Biocontrol Potential of Antagonistic Yeasts on In Vitro and In Vivo Aspergillus Growth and Its AFB1 Production

    • Toxins
    • Aspergillus flavus is a major aflatoxin B1, posing significant health concerns to humans, crops, and producer fungi. Due to the undesirable consequences of the usage of synthetic fungicides, biological control using yeasts has gained more attention. In this study, eight isolates of epiphytic yeasts belonging to Moesziomyces sp., Meyerozyma sp.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins