An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Research Publications (Food Safety)

This page tracks research articles published in national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. Research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies (requires login) and FDA Grant Funding Agencies (requires login) are also tracked in Scopus.

Displaying 1 - 19 of 19

  1. TBBPA and lead co-exposure induces grass carp liver cells apoptosis via ROS/JAK2/STAT3 signaling axis

    • Fish & Shellfish Immunology
    • Tetrabromobisphenol A (TBBPA) and lead (Pb) are widely used in industrial field, which poses a serious threat to human and animal health. In particular, a large volume of wastewater containing TBBPA and Pb was discharged into the aquatic environment, causing a seriously negative impact on fish. Currently, whether TBBPA and Pb have a synergistic toxicity on fish remains unclear.

      • Chemical contaminants
      • Heavy Metals
  2. A novel type II crustin in the innate immune response of the freshwater crab (Sinopotamon henanense) against infection and its expression changes by cadmium

    • Fish & Shellfish Immunology
    • Antibacterial peptide (AMP), an effector of the innate immune system, is an essential component of invertebrate innate immunity. Crustin is a family of antimicrobial peptides that are widely studied in crustaceans. Here we report a novel crustin (designated Shcrustin) from the freshwater crab Sinopotamon henanense.

      • Chemical contaminants
      • Heavy Metals
  3. Melatonin alleviates lead-induced intestinal epithelial cell pyroptosis in the common carps (Cyprinus carpio) via miR-17-5p/TXNIP axis

    • Fish & Shellfish Immunology
    • Lead (Pb) has been concerned as one of the most severe hazardous contaminants, because it can cause pyroptosis in multiple tissues of mammals and birds. Melatonin (Mel) has attracted much interest for its role in governing intestinal injury via 

      • Chemical contaminants
      • Heavy Metals
  4. Cadmium and copper mixture effects on immunological response and susceptibility to Vibrio harveyi in white shrimp Litopenaeus vannamei

    • Fish & Shellfish Immunology
    • Cadmium (Cd2+) and copper (Cu2+) are considered immunotoxic metals and their presence in combination in the aquatic environment may cause effects on shrimp species as Litopenaeus vannamei. Thus, this research evaluates the combined effects of Cd2+ and Cu2+ on shrimp inoculated with Vibrio harveyi bacteria. The experiments were performed at 96-hours of exposure to sublethal concentrations of both metals.

      • Bacterial pathogens
      • Vibrio
      • Chemical contaminants
      • Heavy Metals
  5. Astilbin attenuates apoptosis induced by cadmium through oxidative stress in carp (Cyprinus carpio L.) head kidney lymphocyte

    • Fish & Shellfish Immunology
    • As a kind of environmental pollutant, heavy metal Cadmium (Cd) exists widely in the environment. It is well known that Cd can accumulate and cause damage in liver, kidney and other organs. However, there are few studies on the immune cytotoxicity of Cd to fish. In particular, there are few studies on the toxicity of Cd to the head kidney lymphocytes of common carp. In order to further explore these mechanisms, we established an Cd exposure model in vitro.

      • Chemical contaminants
      • Heavy Metals
  6. Bioaccumulation of arsenic and immunotoxic effect in white shrimp (Penaeus vannamei) exposed to trivalent arsenic

    • Fish & Shellfish Immunology
    • Trivalent arsenic (As (III)) contamination in the marine environment can produce adverse effects in crustaceans. The present study investigated the chronic toxicity of As (III) in white shrimp (Penaeus vannamei) by analyzing the tissue bioaccumulation and non-specific immune responses. Shrimps were exposed to 0 (control), 50, 500, and 2500 μg/L of As (III) for 21 days. The results showed that the hepatopancreas was the main tissue of arsenic accumulation in white shrimp.

      • Chemical contaminants
      • Heavy Metals
  7. Toxic effects of waterborne cadmium exposure on hematological parameters, oxidative stress, neurotoxicity, and heat shock protein 70 in juvenile olive flounder, Paralichthys olicaceus

    • Fish & Shellfish Immunology
    • Cadmium-induced toxicity can affect fish embryo development, ion homeostasis regulation, energy metabolism, maturation and growth, stress response, and immunity. However, studies on the toxic effects of cadmium exposure to aquatic animals, particularly olive flounder (Paralichthys olivaceus), are limited. In this study, juvenile P.

      • Chemical contaminants
      • Heavy Metals
  8. Cadmium regulates FKBP5 through miR-9-5p and induces carp lymphocyte apoptosis

    • Fish & Shellfish Immunology
      • Chemical contaminants
      • Heavy Metals
  9. Cadmium regulates FKBP5 through miR-9-5p and induces carp lymphocyte apoptosis

    • Fish & Shellfish Immunology
    • Author(s): Peixian Luan, Haoran Zhang, Xiaofeng Zhang, Guo Hu, Ziwei Zhang

      • Heavy Metals
      • Chemical contaminants
  10. Dietary α-lipoic acid can alleviate the bioaccumulation, oxidative stress, cell apoptosis, and inflammation induced by lead (Pb) in Channa argus

    • Fish & Shellfish Immunology
    • Author(s): Min Li, Yidi Kong, Xueqin Wu, Zhuang Yin, Xiaotian Niu, Guiqin Wang

      • Heavy Metals
      • Chemical contaminants
  11. Cadmium exposure induces inflammation through the canonical NF-κΒ pathway in monocytes/macrophages of Channa punctatus Bloch

    • Fish & Shellfish Immunology
    • Author(s): Chohelee Choudhury, Ritwik Mazumder, Rajib Biswas, Mahuya Sengupta

      • Heavy Metals
      • Chemical contaminants
  12. Immunity and inflammatory responses in gilthead sea bream (Sparus aurata L.) exposed to sub-lethal mixture of carbamazepine, cadmium chloride and polybrominated diphenyl ether

    • Fish & Shellfish Immunology
    • Author(s): Cristóbal Espinosa-Ruiz, Simona Manuguerra, Maria Morghese, José María García-Beltrán, María Ángeles Esteban, Marta Giuga, Concetta M. Messina, Andrea Santulli

      • Heavy Metals
      • Chemical contaminants
  13. Bisphenol A regulates cytochrome P450 1B1 through miR-27b-3p and induces carp lymphocyte oxidative stress leading to apoptosis

    • Fish & Shellfish Immunology
    • Author(s): Qingqing Liu, Wei Wang, Yiming Zhang, Yuan Cui, Shiwen Xu, Shu Li

      • Chemical contaminants
  14. Identification of novel long non-coding RNAs involved in bisphenol A induced immunotoxicity in fish primary macrophages

    • Fish & Shellfish Immunology
    • Author(s): Shuai Liu, Chenyuan Pan, Yi Tang, Fangyi Chen, Ming Yang, Ke-Jian Wang

      • Chemical contaminants
  15. Cadmium exposure induces apoptosis, inflammation and immunosuppression through CYPs activation and antioxidant dysfunction in common carp neutrophils

    • Fish & Shellfish Immunology
    • Author(s): Sun Jiaxin, Wang Shengchen, Cao Yirong, Wang Shuting, Li Shu

      • Chemical contaminants
      • Heavy Metals
  16. The response of phenoloxidase to cadmium-disturbed hepatopancreatic immune-related molecules in freshwater crayfish Procambarus clarkii

    • Fish & Shellfish Immunology
    • Author(s): Keqiang Wei, Yue Wei, Changxia Song

      • Chemical contaminants
      • Heavy Metals
  17. Clone, identification and functional characterization of a novel toll (Shtoll1) from the freshwater crab Sinopotamon henanense in response to cadmium exposure and Aeromonas hydrophila infection

    • Fish & Shellfish Immunology
    • Author(s): Lang Lang, Minnan Bao, Weixin Jing, Wei Chen, Lan Wang

      • Heavy Metals
      • Bacterial pathogens
      • Chemical contaminants
  18. Transcriptomic profile of oyster Crassostrea gigas hemocyte after short-term cadmium exposure and bacteria stimulation

    • Fish & Shellfish Immunology
    • Author(s): Limei Qiu, Hao Chen, Zhi Zhou, Huan Zhang, Rui Liu, Qilin Yi, Chuanyan Yang, Lei Gao, Lingling Wang

      • Heavy Metals
      • Chemical contaminants
  19. MicroRNA-155 and microRNA-181a, via HO-1, participate in regulating the immunotoxicity of cadmium in the kidneys of exposed Cyprinus carpio

    • Fish & Shellfish Immunology
    • Author(s): Hui Li, Guilan Di, Yi Zhang, Rongrong Xue, Jing Zhang, Junping Liang

      • Heavy Metals
      • Chemical contaminants