Research Publications (Food Safety)

About 19 hydrolyzable tannins were computed against 3CLpro enzyme of 2019‐nCoV. It was found that pedunculagin, tercatain, and castalin interacted with Cys145 and His41 of 2019‐nCoV‐3CLpro. Likewise, pedunculagin‐2019‐nCoV‐3CLpro remain stable, with no obvious fluctuations. We predicted that the understandings obtained in the current study may evidence valued for discovering and unindustrialized novel natural anti‐COVID‐19 therapeutic agents in the near future.

Lysobacter enzymogenes is a nonflagellated, soil proteobacterium that secretes a diffusible antibiotic known as heat‐stable antifungal factor (HSAF) to kill nearby fungi for food. The genome of the model strain OH11 encodes a homologous Wsp system, which is generally deployed by flagellated bacteria to achieve flagella‐dependent outputs via a c‐di‐GMP‐FleQ complex, in which c‐di‐GMP is a ubiquitous dinucleotide second messenger and FleQ is a transcription factor (TF).

Author(s): Changjian Li, Yunfei Xie, Yahui Guo, Yuliang Cheng, Hang Yu, He Qian, Weirong Yao

Author(s): Md Mehedi Hassan, Muhammad Zareef, Tianhui Jiao, Shuangshuang Liu, Yi Xu, Annavaram Viswadevarayalu, Huanhuan Li, Quansheng Chen

Author(s): Jonaina Fiorim, Maylla Ronacher Simões, Bruna Fernandes de Azevedo, Rogério Faustino Ribeiro, Leonardo dos Santos, Alessandra Simão Padilha, Dalton Valentim Vassallo

Lead induces endothelial dysfunction and hypertension in humans and animals. Seven-day exposure to a low dose in rats reduces vasocontractile responses and increases nitric oxide (NO) bioavailability. We hypothesized that this occurs by angiotensin II receptors (AT1/AT2) activation.

ABSTRACT The aim of our work is to investigate and compare the polycyclic aromatic hydrocarbons (PAHs) content of smoked paprika produced with different technologies and originated from different locations.

A new analytical method based on capillary LC with diode array detection has been developed for the simultaneous quantification of seven neonicotinoid insecticides commercially available (imidacloprid, thiacloprid, clothianidin, thiamethoxam, acetamiprid, nitenpyram and dinotefuran) in honey samples.

Significance and Impact of the Study: The occurrence and severity of fungal infections have increased in recent decades due to resistance to available antifungal drugs and the appearance of new emerging pathogens. Thus, the search for new antifungal agents is mandatory. From a series of 23 cinnamyl Schiff bases, two compounds (1 and 23) were interrogated as new anticryptococcal agents without significant cytotoxicity against human lung, kidney or red blood cells.

American foulbrood is one of the most serious and yet unsolved problems of beekeeping around the world, because it causes a disease leading to the weakening of the vitality of honey bee populations and huge economic losses both in agriculture and horticulture. The etiological agent of this dangerous disease is an extremely pathogenic spore-forming bacterium, Paenibacillus larvae, which makes treatment very difficult.

The antibiotic residues were investigated in raw and pasteurized milk produced in Neyshabur region, Iran. To this end, 82 milk samples, including raw and pasteurized milk of different brands and local raw milk samples of collection centers, were collected from Neyshabur region in two seasons during 2016. The antibiotic four-plate test (FPT) was performed to examine the presence of tetracycline, flomocaine, sulfonamide, enrofloxacin, aminoglycoside, and macrolide in the samples.

Author(s): Jun Wang, Hui-Ling Duan, Li Fan, Jing Zhang, Zhi-Qi Zhang

Plant diseases caused by viruses and fungi have posed a serious threat to global agricultural production. The discovery of new leads based on natural products is an important way to innovate pesticides. In this work, natural product luotonin A was found to have good antiviral activity against tobacco mosaic virus (TMV) for the first time. A series of luotonin A derivatives were designed, synthesized, and evaluated for their antiviral activities and fungicidal activities systematically.

Author(s): Paola Caroline Lacerda Leocádio, Ronaldo Pereira Dias, Daniel Vieira Pinto, Jonas Martins Reis, José Carlos Rodrigues Nascimento, Gerly Anne de Castro Brito, José Telmo Valença, Giselle Foureaux, Anderson José Ferreira, Cláudia Carvalhinho Windmöller, Maria Elena Crespo-Lopez, Flávia Almeida Santos, Reinaldo Barreto Oriá, Jacqueline I. Alvarez-Leite

Author(s): Ewa Muszyńska, Mateusz Labudda

In humans, sexual dimorphism can manifest in many ways and it is widely studied in several knowledge fields. It is increasing the evidence that also cells differ according to sex, a correlation still little studied and poorly considered when cells are used in scientific research. Specifically, our interest is on the sex-related dimorphism on the human mesenchymal stem cells (hMSCs) transcriptome.

Author(s): Talha Burki

Mainly resulting from cookware and recycled batteries, lead exposure, even at low concentrations, can result in cognitive and neurological problems. Talha Burki reports.

Author(s): Ran Xu, Yue-Hong Zhao, Qing-Zhen Han, Peng-Ge Ning, Hong-Bin Cao, Hao Wen

Antimicrobial peptides (AMPs) are promising candidates for new therapeutics to combat the emergence of an increasing number of multidrug-resistant pathogens. However, a major obstacle to the systemic application of AMPs is their possible toxicity. In this study, we improved the therapeutic index of the typical AMP F5W-magainin 2 by simultaneously introducing positive charges (+9–+10) and Pro residues.

The aim of this study was to investigate, analyze, and compare applied techniques suitable for achieving efficient removal of organophosphorus pesticides (OPPs) (malathion and fenitrothion) from aqueous solutions and analyze the degradation products and processes. Pesticide degradation efficiency (%) was monitored by high-performance liquid chromatography (HPLC) equipped with a photodiode array detector (DAD), while mineralization degree was determined by total organic carbon analysis (TOC).

The pollution of agricultural soil due to heavy metals is a serious environmental problem throughout the world due to their persistence and toxicity. The present study was carried out on agricultural soils of district Bathinda, Punjab where a total of 120 soil samples were collected from 40 different locations during pre-monsoon, monsoon, and post-monsoon season.

Several analgesic α-conotoxins have been isolated from marine cone snails. Structural modification of native peptides has provided potent and selective analogues for two of its known biological targets—nicotinic acetylcholine and γ-aminobutyric acid (GABA) G protein-coupled (GABAB) receptors. Both of these molecular targets are implicated in pain pathways.

Author(s): Manisha Gautam, Shivani Katoch, Rakesh Kumar Chahota

Author(s): Shan Wang, Jiayi Wang, Chen Li, Yaping Xu, Zhaoxia Wu

Author(s): Xiufen Liao, Congjin Chen, Panpan Shi, Lizhou Yue

Author(s): Qian Bu, Yan Huang, Meng Li, Yanping Dai, Xin Fang, Ke Chen, Qian Liu, Aiqin Xue, Kai Zhong, Yina Huang, Hong Gao, Xiaobo Cen