Research Publications (Food Safety)

Bilobetin, a natural compound extracted from Ginkgo biloba, has various pharmacological activities such as anti‐oxidation, anti‐cancer, anti‐bacterial, anti‐fungal, anti‐inflammatory, anti‐viral, and promoting osteoblast differentiation. However, few studies have been conducted and there are no reports on its metabolites owing to its low content in nature. In addition, it has been reported to have potential liver and kidney toxicity.

A novel, facile, and robust strategy was proposed to increase the pore size and mechanical strength of cryogels. By mixing the monomers of acrylamide and 2‐hydroxyethyl methacrylate as the precursor, a monolithic copolymer cryogel with large interconnected pores and thick pore walls was prepared. Hydrogen bonding between the two monomers contributed to the entanglement and aggregation of the copolymers, thickening the pore walls and resulting in larger pore sizes.

Roukou Wuwei pills is one of the most commonly used Mongolian medicinal prescriptions and historically used for the treatment of depression. This research aimed to illustrate the metabolic characteristic of Roukou Wuwei pills in vivo. To address this objective, an ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry method based metabonomics approach was used to detect and analyze the metabolites of Roukou Wuwei pills.

In this work, a simple, fast, sensitive, and environmentally friendly method was developed for preconcentration and quantitative measurement of bisphenol A in water samples using GC‐MS instrument.

A fast, green, sensitive, and accurate analytical method using HPLC couple with fluorescence detection, was established and validated for the simultaneous determination of amlodipine besylate and celecoxib in their recently approved fixed‐dose combination tablets (1:20).

A mesoporous silica was functionalized by carbon nanotubes to enhance the extraction performance. The mesoporous material was coated on stainless steel wires, and three wires were inserted inside of a polyetheretherketone tube for in‐tube solid‐phase microextraction.

Graphene oxide has received extensive attention because of its unique properties and potential applications. In this study, magnetic nitrogen‐doped graphene was prepared by one‐step hydrothermal reaction using urea as the dopant and reductant, and ferroferric oxide nanoparticles were in‐situ deposited on the surface of the nanohybrids. The magnetic nitrogen‐doped graphene was characterized using various physical and chemical methods.

In this work, various types of metal‐organic frameworks were synthesized, and their affinities towards buprenorphine were evaluated using dispersive solid‐phase extraction. The extracted buprenorphine was determined by ultra‐performance liquid chromatography‐ultraviolet detection system. The highest extraction recovery was observed by employing zeolitic imidazole framework‐67. Then, a facile and fast extraction method was designed for the extraction and purification of the target drug.

A new sol‐gel hybrid methyltrimethoxysilane‐chloropropyltriethoxysilane was prepared as sorbent for solid phase extraction. The extraction efficiency of the prepared sol‐gel hybrid methyltrimethoxysilane‐chloropropyltriethoxysilane were assessed by using three selected organophosphorus pesticides namely chlorpyrifos, profenofos and malathion. Gas chromatography‐mass spectrometry was used for detection of organophosphorus pesticides.

In this study, the new and efficient three‐dimensional network porous aromatic frameworks materials called as Silica‐PAFs‐a, Florisil‐PAFs‐a, Silica‐PAFs‐b and Florisil‐PAFs‐b were first synthesized. The properties of materials were analyzed by five characterization methods. And they were used as adsorbents in pipette‐tip solid‐phase extraction for the effective determination of carbendazim and thiabendazole in spinach sample.

A novel solid‐phase microextraction fiber was synthesized by coating of stainless steel wire with polyoxomolybdate368/polyaniline as a sorbent aimed at extraction of amitriptyline, nortriptyline and doxepin as antidepressant drugs from urine and blood samples. The polyoxomolybdate368/polyaniline composite coating was carried out using electropolymerization process under constant potential. This composition leads to enhanced extraction efficiency of the fiber.

Monitoring biological samples at trace levels of chemicals from anthropogenic actions such as pesticides, pharmaceuticals and hormones has become a very important subject. This work describes a method for the determination of 8 compounds of different chemical classes in human urine samples. Dispersive liquid‐liquid microextraction based on magnetic ionic liquids was used as the sample preparation procedure.

Kang‐Ai injection, which is composed of Astragali Radix, Ginseng Radix, et Rhizoma, and kushenin, is extensively used in China as an adjuvant therapy for many types of cancer and chronic hepatitis B.

In the present work, a novel database of drug compounds and a rapid screening method based on ultra‐high performance liquid chromatography coupled to high resolution orbitrap mass spectrometry were developed and applied in the screening and identification of targeted and non‐targeted antihypertensive adulterants in dietary supplements and herbal medicines.

A solid phase microextraction with carbon nanospheres coated fiber coupled with gas chromatographic detection was established for the determination of eight polycyclic aromatic hydrocarbons (naphthalene, biphenyl, acenaphthene, fluorine, phenanthrene, anthracene, fluoranthene and pyrene) in water and soil samples.

Amphiphilic diblock copolymers consisting of a hydrophobic core containing a polymerized ionic liquid and an outer shell composed of poly(N‐isoprolylacrylamide) were investigated by CE and asymmetrical flow field flow fractionation. The polymerized ionic liquid comprised poly(2‐(1‐butylimidazolium‐3‐yl)ethyl methacrylate tetrafluoroborate) with a constant block length (n = 24), while the length of the poly(N‐isoprolylacrylamide) block varied (n = 14; 26; 59; 88).

ABSTRACT In this research, a new ultrasonic‐assisted dispersive micro solid‐phase extraction method based on N‐doped mesoporous carbon sorbent followed by high‐performance liquid chromatography equipped with diode array detector for trace measurement of 1‐hydroxypyrene as a metabolite of exposure to polycyclic aromatic hydrocarbons was optimized. Herein, the hard template method was used for the preparation of N‐doped mesoporous carbon sorbent.

A novel ecofriendly, cost and time saving high performance thin layer chromatographic method was developed and validated for simultaneous determination of metoclopramide, ergotamine, caffeine and paracetamol in bulk and pharmaceutical formulation. The separation was carried out on silica gel plates, using ethyl acetate: ethanol: ammonia (9: 1: 0.1, by volume) as a developing system. Ultra violet detection was carried out at 272 nm.

Saxitoxin, which is one of the most typical paralytic shellfish poisoning toxins, ranks the highest intoxication rate of marine biological poisoning cases globally. Efficient clean‐up and extraction of saxitoxin from complex biological matrices are imperative for the analysis and concentration monitoring of the toxin when correlative poisoning cases happen.

Two HPLC‐MS/MS methods were developed and validated for the quantification of edaravone (method A) or taurine (method B) in human plasma. After protein precipitation, separations were achieved on an Ultimate XB‐C8 (2.1 × 50 mm, 3.0 μm) column for edaravone and a ZORBAX SB‐Aq column (2.1 × 100 mm, 3.5 μm) for taurine, respectively.

ABSTRACT Pesticides have posed significant threats to aquatic ecosystems, yet little is known about their transformation products. The challenge is to simultaneously analyze various pesticides and transformation products in water as they have distinct physicochemical properties.

Anabolic androgenic steroids are widely abused substances in sports doping. Their detection present limitations regarding the use of soft ion sources such as electrospray or atmospheric pressure chemical ionization by LC‐MS/MS. In the current study, a novel derivatization method was developed for the ionization enhancement of selected anabolic androgenic steroids.

In this study, a green mode of solidification of floating organic droplet–based dispersive liquid–liquid microextraction has been developed for the extraction of sixteen polycyclic aromatic hydrocarbons from honey samples before their determination by gas chromatography–mass spectrometry. In this method, an appropriate volume of menthol:decanoic acid deep eutectic solvent (as an extraction solvent) is added on a sugar cube (as a disperser agent).

This paper describes the synthesis and application of a magnetic amino‐functionalized hollow silica‐titania microsphere as a new sorbent for magnetic dispersive micro‐solid phase extraction of selected pesticides in coffee bean samples. The sorbent was fully characterized by Fourier transforms infrared spectroscopy, field emission scanning electron microscopy, transition electron microscopy, energy‐dispersive X‐ray spectroscopy, and vibrating sample magnetometer techniques.

An ultra‐performance liquid chromatography‐tandem mass spectrometric method has been developed for the highly sensitive and selective determination of regulated aflatoxins. The extraction of aflatoxins from baby food matrices were performed using liquid–liquid extraction procedure followed by immunoaffinity column cleanup.