Research Publications (Food Safety)

Heat-labile toxin (LT) is a well-characterized powerful enterotoxin produced by enterotoxigenic Escherichia coli (ETEC). This toxin is known to contribute to diarrhea in young children in developing countries, international travelers, as well as many different species of young animals. Interestingly, it has also been revealed that LT is involved in other activities in addition to its role in enterotoxicity.

Giardia lamblia, a single-celled eukaryote, colonizes and thrives in the small intestine of humans. Because of its compact and reduced genome, Giardia has adapted a “minimalistic” life style, as it becomes dependent on available resources of the small intestine. Because Giardia expresses fewer sphingolipid (SL) genes—and glycosphingolipids are critical for encystation—we investigated the SL metabolic cycle in this parasite.

Salmonella enterica serotype Typhimurium is a major global food-borne pathogen and causes life-threatening infections. Although the resistance mechanisms to fluoroquinolones in S. Typhimurium had been well defined, tolerance to fluoroquinolones and the associated mechanism for this are obscure. In the current work， we investigated an oqxAB-positive plasmid pHXY0908 and analyzed its role in S. Typhimurium tolerance to ciprofloxacin using time-kill, transcriptome sequencing and real-time PCR.

The lifecycle of the causative agent of the severe secretory diarrheal disease cholera, Vibrio cholerae, is characterized by the transition between two dissimilar habitats, i.e. as a natural inhabitant of aquatic ecosystems and as a pathogen in the human gastrointestinal tract. V. cholerae faces diverse stressors along its lifecycle, which require effective adaptation mechanisms to facilitate the survival fitness.

Campylobacter jejuni outer membrane vesicles (OMVs) contain numerous virulence-associated proteins including the cytolethal distending toxin and three serine proteases. As C. jejuni lacks the classical virulence-associated secretion systems of other enteric pathogens that deliver effectors directly into target cells, OMVs may have a particularly important role in virulence. C.

Enteroaggregative Escherichia coli (EAEC) infections are one of the most frequent causes of persistent diarrhea in children, immunocompromised patients and travelers worldwide. The most prominent colonization factors of EAEC are aggregative adherence fimbriae (AAF). EAEC prototypical strain 042 harbors the AAF/II fimbriae variant, which mediates adhesion to intestinal epithelial cells and participates in the induction of an inflammatory response against this pathogen.

Integrative Analyses of Long Non-coding RNA and mRNA Involved in Piglet Ileum Immune Response to Clostridium perfringens Type C Infection

Anna-Maria Schmidt, Ulrike Escher, Soraya Mousavi, Manja Boehm, Steffen Backert, Stefan Bereswill, Markus M. Heimesaat

Shijun Li, Ying Liu, Yue Wang, Ming Wang, Chunting Liu, Yi Wang

Jussa-Pekka Virtanen, Riikka Keto-Timonen, Kaisa Jaakkola, Noora Salin, Hannu Korkeala Yersinia pseudotuberculosis is a bacterium that not only survives, but also thrives, proliferates, and remains infective at cold-storage temperatures, making it an adept foodborne pathogen. We analyzed the differences in gene expression between Y. pseudotuberculosis IP32953 grown at 3 and 28°C to investigate which genes were significantly more expressed at low temperature at different phases of growth.

Shama Mujawar, Derek Gatherer, Chandrajit Lahiri

M. Soledad Hielpos, Andrea G. Fernández, Juliana Falivene, Iván M. Alonso Paiva, Florencia Muñoz González, Mariana C. Ferrero, Priscila C. Campos, Angelica T. Vieira, Sergio Costa Oliveira, Pablo C. Baldi

Garima Arora, Deepika Chaudhary, Saqib Kidwai, Deepak Sharma, Ramandeep Singh

Zujie Yao, Lina Sun, Yuqian Wang, Ling Lin, Zhuang Guo, Dong Li, Wenxiong Lin, Xiangmin Lin

Sumit Kumar, Trpta Bains, Ashley Sae Won Kim, Christina Tam, Jong Kim, Luisa W. Cheng, Kirkwood M. Land, Anjan Debnath, Vipan Kumar

Betina Hebbelstrup Jensen, Camilla Adler Sørensen, Stig Hebbelstrup Rye Rasmussen, Dorthe Rejkjær Holm, Alice Friis-Møller, Jørgen Engberg, Hengameh C. Mirsepasi-Lauridsen, Carsten Struve, Anette M. Hammerum, Lone Jannok Porsbo, Randi Føns Petersen, Andreas Munk Petersen, Karen Angeliki Krogfelt

Samuel Lebourgeois, Audrey Fraisse, Catherine Hennechart-Collette, Laurent Guillier, Sylvie Perelle, Sandra Martin-Latil

Karolina Jaworska, Marta Nieckarz, Marta Ludwiczak, Adrianna Raczkowska, Katarzyna Brzostek

Jeffrey K. Schachterle, Ryan M. Stewart, M. Brett Schachterle, Joshua T. Calder, Huan Kang, John T. Prince, David L. Erickson

Xingchen Zhao, Xudong Tang, Na Guo, Yanan An, Xiangrong Chen, Ce Shi, Chao Wang, Yan Li, Shulin Li, Hongyue Xu, Mingyuan Liu, Yang Wang, Lu Yu

Yiquan Zhang, Lingfei Hu, George Osei-Adjei, Ying Zhang, Wenhui Yang, Zhe Yin, Renyun Lu, Xiumei Sheng, Ruifu Yang, Xinxiang Huang, Dongsheng Zhou

Emanuela Marini, Gloria Magi, Gianna Ferretti, Tiziana Bacchetti, Angelica Giuliani, Armanda Pugnaloni, Maria Rita Rippo, Bruna Facinelli

Huynh T. Hop, Lauren T. Arayan, Tran X. N. Huy, Alisha W. B. Reyes, Son H. Vu, WonGi Min, Hu J. Lee, Man H. Rhee, Hong H. Chang, Suk Kim

Muhammad A. B. Shabbir, Yanping Tang, Zihui Xu, Mingyue Lin, Guyue Cheng, Menghong Dai, Xu Wang, Zhengli Liu, Zonghui Yuan, Haihong Hao

Sylvie M. Roche, Sébastien Holbert, Jérôme Trotereau, Samantha Schaeffer, Sonia Georgeault, Isabelle Virlogeux-Payant, Philippe Velge