2022 FARAD - UF COMPONENT

The goals for the University of Florida FARAD component for 2022-2023 are: (1) to continue to develop physiologically-based pharmacokinetic (PBPK) models for various drugs in food animal species for withdrawal interval estimations, focusing on models for meloxicam in broiler chickens and laying hens, as well as florfenicol in sheep and goats; (2) convert previously-developed PBPK models into user-friendly, web-based, interactive interfaces, so that FARAD responders can use these to predict withdrawal intervals; (3) continue ongoing work to develop a generic interactive PBPK platform that allows responders to run simulations and predict withdrawal intervals of different drugs efficiently and rapidly; (4) work with the FARAD centers at Kansas State University, University of California Davis, Virginia Tech and North Carolina State University to validate computational estimates of a safe withdrawal time, and provide other pharmacokinetic support as needed; (5) develop new machine learning and artificial intelligence models that can predict withdrawal intervals of different drugs in different species; (6) continue to support and update the US Approved Animal Drugs Database by addition of new FDA data on drug use in food animal species as it becomes available. This database is essential for the function of FARADs' web-based and responder services; (7) support, maintain and update all web-based interfaces and electronic resources, including the FARAD website (www.farad.org), the Veterinarian's Guide to Residue Avoidance Management (VetGRAM) which is an on-line tool for finding established recommendations for drug withdrawal intervals, mobile apps for smartphones, and, together with other FARAD centers, develop a searchable database and tool for veterinary feed directive drugs; (8) conduct outreach and education of veterinarians on drug residue avoidance through social media, FARAD Digests for publication in the Journal of the American Veterinary Medical Association, and by representation at state and national meetings.