Adaptation in Polyphenol Bioavailability and Bioactivity During Long Term Exposure to Polyphenol-rich Foods in Lean and Obese Individuals

The goals of this project are to assess differential response in bioavailability and metabolic pathways between lean and obese individuals exposed to acute, short term (10-day), and long-term (10-week) consumption of polyphenol-rich fruits (blueberry and apple) and beverages (tea); determine the differential systemic and gut anti-inflammatory response between obese and lean individuals exposed to polyphenol-rich fruits (blueberry and apple) and beverages (tea); and identify mechanisms related to adaptation in polyphenol absorption, metabolism, and modulation of inflammatory processes in the GI tract.