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Identify and characterize vaccine targets for important viral and bacterial pathogens of livestock. Identify and characterize important factors involved in optimizing host responses to pathogens of livestock. Define molecular mechanisms of virulence and host range of pathogenic bacteria and viruses. Perform epidemiologic and other surveys sufficient to identify and design enhanced diagnostic capabilities for important pathogens of livestock. All in keeping with National Program Priorities.
Approach- Conduct basic investigations into the mechanisms of pathogenisis, diagnostics, immune modulation of and vaccine designs for Mycoplasma gallisepticum, mycoplasma mycoides, Foot-and-Mouth Disease Virus, and Avian Influenza Virus. Genetically manipulate (mutate) specific genes and analyze the resultant clones in host animals. Develop a model in vitro system with which to characterize both the induction and antiviral action of bovine interferon and related cytokines and gene products at the cellular and molecular level, with a view toward exploiting this system for the purpose of controlling bovine virus infections of importance, in particular VSV, FMDV and other vesiculoviruses.