Application Of Hormonal Biomarkers For Don-3-Glucoside Risk Assessment

Objective

Discern whether DON-3-G is sufficiently toxic to be included in the tolerable daily intake (TDI) for DON.

More information

Compare the effects of DON and DON-3-G on (1) [Ca2+]i elevation and CCK release in the cloned STC1 EEC model and (2) [Ca2+]i elevation and 5-HT secretion in cloned EC cell models. Compare the effects of DON and DON-3-G on (1)CCK release in primary murine I-cell-containing models, (2) PYY release in primary murine L-cell-containing models and (3) 5-HT secretion from intestinal whole mount preparations from mice and mink.

Investigators

Costa, Jose

Institution

Michigan State University

Start date

2014

End date

2016

Funding Source

Nat'l. Inst. of Food and Agriculture

Project number

0500-00053-003-68G

Accession number

426686