BROADLY PROTECTIVE PORCINE STREPTOCOCCUS SUIS VACCINES

The major goal is to develop a multi-component protein sub-unit vaccine that can broadly protect pigs from Streptococcus suis infection / disease caused by disparate clinically relevant serotypes / variants implicated in the casuation of disese globally. The objectives of this project to realize the above major goal include (i) generation of a multivalent protein subunit vaccine comprising of proteins shared by the majority of the disease-causing serotypes, and optimization of both vaccine formuation and immunization regimen to confer robust protection; and (ii) Evaluation of vaccine efficacy, i.e., the abillity of the multi-component protein subunt vaccine to protect pigs against 15 disparate clinically relevant S. suis serotypes implicated in porcine disease world-wide.