Chemical Inactivation of Protein Toxins on Food Contact Surfaces

Objective

1) Identify cleaning/sanitizing treatments that result in elimination and/or inactivation of protein toxins (abrin and ricin) on food-contact surfaces. <br>
2) Identify surrogate(s) that can be used to study chemical inactivation of abrin or ricin. <br>
3) Measure the loss of ricin and abrin biological and biochemical activities in the presence of cleaning/sanitizing solutions using RAW264.7 macrophage cytotoxicity assays and 28S rRNA adenosine N-glycosidase RTqPCR-based enzyme assays.

More information

Responsible Division: Biochemical Toxicology <P>
Collaborating FDA Center(s): CFSAN

Investigators

Tolleson, William

Institution

DHHS/FDA - National Center for Toxicological Research

Start date

2011

End date

2012

Funding Source

Food and Drug Administration

Project number

E0730301