This research project aims to examine the potential cytotoxicity of cockle extract that gives rise to the atypical response in the diarrhetic shellfish poisoning (DSP) mouse bioassay (MBA).
<p>This research project aims to examine, using conventional cell-based assays, any potential cytotoxicity of cockle extracts that gives rise to the atypical response in the DSP assay.
<p>The study will determine cytotoxicity by investigating whether the cockle extracts adversely affect the capacity of cells to function normally, degrade cell membranes and/or initiate programmed cell death.
Since June 2001, atypical responses have been observed during the diarrhetic shellfish poisoning (DSP) mouse bioassay (MBA) used within the UK statutory biotoxin monitoring programme.
<p>These have occurred primarily from cockles from England, Wales and Northern Ireland, but also from small numbers of mussels from England and Wales.
<p>This project will examine the potential cytotoxicity of cockle extract that give rise to the atypical response in the DSP MBA.
<p>Find more about this project and other FSA food safety-related projects at the <a href="http://www.food.gov.uk/science/research/" target="_blank">Food Standards Agency Research webpage</a>.