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National Agricultural Library
U.S. Department of Agriculture
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  4. A Collaborative Research Proposal to Assess Cancer Risk Posed by Intermittent Exposure to Aflatoxin B1 in Rats

A Collaborative Research Proposal to Assess Cancer Risk Posed by Intermittent Exposure to Aflatoxin B1 in Rats

Objective

1. To test the hypothesis that a chemically induced tumor incidence is a function of the accummulated lifetime exposure, and is predictable from the average daily dose for various dosing regimens, such as continous and intermittent dosing; 2. To study correlations between the chemically-induced tumor incidence and various biomarkers of the initiation and the promotion stage of carcinogenesis for continuous and intermittent dosing.

Investigators
Harris, Angela
Institution
DHHS/FDA - National Center for Toxicological Research
Funding Source
Nat'l. Center For Toxicological Research
Project number
E0688801
Categories
Mycotoxins
Sanitation and Quality Standards