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National Agricultural Library
U.S. Department of Agriculture
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  4. Control of Signaling Molecules Regulating Aspergillus Development and Aflatoxin Production

Control of Signaling Molecules Regulating Aspergillus Development and Aflatoxin Production

Objective

<ol> <li>To control aflatoxin contamination by deciphering how the pH regulatory gene, pacC, regulates aflatoxin production, and
<li>Elucidating lipid signaling between seed and Aspergillus.</ol>

More information

<ol> <li>Investigate the role of pacC through mutagenesis of pacC and PacC binding sites in promoter of aflatoxin genes.Cooperative study with USDA-ARS, New Orleans. <li>Identify the lipid metabolism genes that are induced and suppressed in the Aspergillus/seed interaction via transcriptional profiling. Functionally define the lipid signaling genes in Aspergillus through gene disruption. Eliminate the Aspergillus spore inducing and aflatoxin inducing seed lipids (e.g. 9 hydroperoxy linoleic acid) and/or introduce Aspergillus aflatoxin inhibiting seed lipids (e.g. 13 hydroperoxy linoleic acid) in cooperation with ARS with plant transformation skills.</ol>

Investigators
Keller, Nancy
Institution
Texas A&M University
Start date
2000
End date
2005
Funding Source
Agricultural Research Service
Project number
6435-41420-003-01S
Accession number
403573
Categories
Mycotoxins