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National Agricultural Library
U.S. Department of Agriculture
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  4. Control of Signaling Molecules Regulating Aspergillus Development and Aflatoxin Production

Control of Signaling Molecules Regulating Aspergillus Development and Aflatoxin Production

Objective

<ol> <li>To investigate regulation of aflatoxin biosynthesis by examining AflJ protein interaction with other factors, and <li>Elucidating lipid signaling between seed and Aspergillus.</ol>

More information

<ol> <li>Investigate the function of the aflJ gene and the mechanism(s) of the AflJ protein in promoting aflatoxin biosynthesis through mutagenesis and protein-protein interaction assays. Identify protein factor(s) that interact with the AflJ protein. Cooperative study with USDA-ARS, New Orleans.
<li>Identify the lipid metabolism genes that are inducted and suppressed in the Aspergillus/seed interaction via transcriptional profiling. Eliminate the Aspergillus spore inducing and aflatoxin inducing seed lipids (e.g. 9 hydroperoxy linoleic acid) and/or introduce Aspergillus aflatoxin inhibiting seed lipids (e.g. 13 hydroperoxy linoleic acid) in cooperation with ARS with plant transformation skills.</ol>

Investigators
Chang, Perng
Institution
University of Wisconsin - Madison
Start date
2001
End date
2005
Funding Source
Agricultural Research Service
Project number
6435-41420-004-01S
Accession number
404306
Categories
Mycotoxins