<UL> <LI>To develop improved methods to separate cottonseed glands from cottonseed and facilitate large-scale isolation of gossypol. <LI>To develop novel gossypol chemistries to improve analytical methods and to support bioactivity studies.<LI> To provide gossypol analytical services or support as needed.
Approach: Cottonseed will be milled to free pigment glands. Glands will be recovered with a vibratory table. Gossypol will be isolated from the separated glands and characterized. Chemical modification will be studied to improve analytical detection of the compound and to improve biological activity.