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National Agricultural Library
U.S. Department of Agriculture
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  4. Creation and Preparation of Monoclonal Antibodies for Use in Biological Toxins Detection Assays

Creation and Preparation of Monoclonal Antibodies for Use in Biological Toxins Detection Assays

Objective

To develop a panel of monoclonal antibodies that will be used to develop sensitive immunoassays for detection of multiple serotypes of botulinum neurotoxin.

More information

Approach:
Monoclonal anti-toxin antibodies for serotypes B and E will be developed using chemical cell fusion methods following immunization with toxoids, toxins, or recombinant peptides. In addition, antibodies to nontoxin associated proteins will be developed. The monoclonal antibodies will be supplied to DHS contractors and other collaborating federal laboratories in order to format sensitive immunoassays for toxin identification.

Investigators
Stanker, Larry
Institution
USDA - Agricultural Research Service
Start date
2010
End date
2014
Funding Source
Agricultural Research Service
Project number
2030-42000-048-06-R
Accession number
418961
Categories
Natural Toxins
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