Detection and Treatment Options For Mastitis Treatment and Prevention of Mastitis in Caprines and Subsequent Drug Residues and Drug Resistances in Caprine Milk

GOAL # 1: To determine the inhibitory effect of various probiotics (Lactobacillus plantarum v. commercially available probiotics) on the growth of Staphylococcus aureus isolated from lactating dairy goats. Once the probiotic exhibiting the highest inhibitory effect is determined, this product will be fed to goats and the somatic cell count will be evaluated to determine if probiotics are beneficial in decreasing subclinical mastitis in goatsObjectives:1. To decrease somatic cell count in milk due to mastitis by 40% (post-treatment) using oral probiotics.2. To decrease somatic cell count in milk due to mastitis by 40% (post-treatment) using intramammary infusion of probiotics.3. To effectively treat sub-clinical mastitis in dairy goats yielding a 70% cure rate through use of oral probiotics.4. To effectively treat clinical mastitis in dairy goats yielding a 70% cure rate through use of oral probiotics.5. To effectively treat sub-clinical mastitis in dairy goats yielding a 70% cure rate
through use ofintramammaryprobiotics.6.To effectively treat clinical mastitis in dairy goats yielding a 70% cure rate through use ofintramammaryprobiotics.GOAL # 2To identify the presence of antibiotic resistance and antibiotic residue in dairy goat milk.Objectives:1. Establish a percentage of goats displaying resistance and residueto Penicillin G past manufacturer guidelines.2. Establish a percenage of goats displaying resistance and residueto Amoxicillin and Ampicillin past manufacturer guidelines.3. Establish a percentage of goats displaying resistance and residueto Ceftiofer and Cephapircin past manufacturer guidelines .4. Establish a percentage of goats displaying resistance and residueto the Tetracycline class of antibiotics past manufacturer guidelines.5. Establish a percentage of goats displaying resistance and residueto the Aflatoxin M-1 class of antibiotics past manufacturer guidelines.6. Establish a percentage of goats displaying resistance and residueto the Gentamycin
class of antibiotics past manufacturer guidelines.7. Establish a percentage of goats displaying resistance and residueto the Sulfamethazine class of antibiotics past manufacturer guidelines.GOAL # 3: To compare the efficacy of a commercially available probiotic versus a compounded intra-mammary infusion on both subclinical and clinical mastitis.1. To determine the percentage of goats with favorable outcome through treatment of sub-clinical mastitis with commercilly available probiotic usage.2. To determine the percentage of goats with favoable outcome through treatment of clinical mastitis with commercially available probiotic usage.3. To determine the percentage of goats with favorable outcomes through treatment of sub-clinical mastitis with compounded intra-mammary infusion.4. To determine the percentage of goats with favorable outcomes through treatment of clinical mastitis with compouned intra-mammary infusion.GOAL # 4: Assist small and economically challenged farmers by
increasing the safety of their milk product.1. Decrease the amount of sub-clinical and clinical mastitis on farms through the use of probiotics.2. Increase the amount of viable milk products that are available as a result of less mastitis in dairy herds due to use of probiotics.