DEVELOPING VACCINE AND BILE ACID INTERVENTIONS TO PREVENT CHICKEN NECROTIC ENTERITIS

Our long-term goal is to contribute toward the development of mechanism-based interventions to mitigating poultry necrotic enteritis. We plan to fulfill the long term goal with the following specific objectives. 1) We will develop multiepitope fusion antigens vaccines of C. perfringens polyvalent factors to reduce chicken NE. 2) We will develop microbe-metabolized bile acid regiments to reduce C. perfringens virulence and chicken NE. At the completion of the proposed research, the results of this continuum of research will have an important positive impact by contributing meaningfully toward the development of mechanism-based strategies to prevent poultry NE.