DEVELOPMENT OF A BROADLY PROTECTIVE VACCINE AGAINST SWINE INFLUENZA VIRUS

The ultimate goal of this proposed research is to develop a novel vaccine against IAV-S that would elicit the broadest level of heterologous protection.The availability of such a vaccine will provide swine producers with an effective tool to reduce the potential economic impact of IAV-S, thereby, enhancing the sustainability and competitive advantage of the U.S. swine industry. The specific objectives of these project are:Objective 1: To generate and in vitro characterize recombinant PICV expressing consensus IAV-S HA immunogens.Objective 2: To evaluate safety and immunogenicity of the recombinant PICV-vector expressing consensus HA immunogens in pigs.Objective 3: To evaluate the cross-protective efficacy of the recombinant PICV-expressing consensus HA immunogens in pigs.