DIETARY MANIPULATION OF SATELLITE CELL BIOACTIVITIES TO PROMOTE REPAIR AND HYPERTROPHY

The requirement for satellite cells (SCs) for muscle growth is unequivocal thus, supporting the need for an improved understanding of their regulatory control in the postnatal animal. While a vast amount of literature details the importance of the fiber niche to SC function, a gap in knowledge exists in how modification of said niche can alter bioactivity of the heterogeneous population.The grant hypothesis is that multiple subsets of SC exist whose bioactivities can be augmented through dietary modification of the systemic milieu, muscle fiber metabolome and its lamin associated niche. Specifically the goals of the project are to 1) identify distinct fusogenic and self-renewing SCs subclasses and 2) examine the functional outcomes of oxidative and glycolytic fiber metabolism on the adjacent SC and its supporting niche.