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We propose to quantify those variables that are known to affect the outcome of control programs. This will be achieved through three independent but related experiments:
the first will define the average life-span of a T. solium tapeworm, the second will quantify environmental contamination after treating the human population for adult tapeworm, and the third will define the effect of a combined human and porcine intervention in terms of parasitic infection burden.
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Control measures for Taenia solium infection in both human and porcine populations are currently impractical and inadequate in disease endemic areas. A series of specific control measures, in addition to abattoir inspection, must be instituted to prevent human and swine Cysticerosis. No control measure has proven effective and sustainable to date. </p>
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A better understanding of the transmission and infection dynamics of T. solium is necessary to lay the foundations for a successful eradication strategy in terms of realistic time frame, biological impact, and economic plausibility. </p>
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We propose to quantify those variables that are known to affect the outcome of control programs. This will be achieved through three independent but related experiments: the first will define the average life-span of a T. solium tapeworm, the second will quantify environmental contamination after treating the human population for adult tapeworm, and the third will define the effect of a combined human and porcine intervention in terms of parasitic infection burden. </p>
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On the basis of the information, we will then develop and validate a new simulation model for T. solium and propose a plausible eradication program suitable for the Peruvian highlands.</p>