ESTABLISHING A PAN-EPIGENOME FOR CATTLE AND SHEEP

The overarching goal of this project is to establish a cattle and sheep pan-epigenome. To accomplish this goal, we plan to accomplish the following specific aims: 1) Comprehensive characterization of epigenetic diversity in multiple breeds of cattle and sheep which will serve as the basis for the bovine and ovine pan-epigenome. 2.) Identify epigenetic variation with potential to impact phenotype. 3.) Employ comparative epigenomics to identify consensus epigenomes shared between sheep and cattle.