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National Agricultural Library
U.S. Department of Agriculture
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  4. Evaluation and Development of Vaccines and Vaccine Seed Strains for H5N1 High Pathogenicity Avian Influenza Control in Indonesia

Evaluation and Development of Vaccines and Vaccine Seed Strains for H5N1 High Pathogenicity Avian Influenza Control in Indonesia

Objective

<OL> <LI> Determine the ability of current vaccine seed strains to protect chickens against emerging H5N1 high pathogenicity avian influenza field viruses. <LI> Develop serological reagents for use within in vitro tests to detect HPAI antigenic variants.

More information

APPROACH: Commercial avian influenza (AI) vaccines, vaccine seed strains and field H5N1 high pathogenicity (HP) AI viruses will be obtained from Indonesia. Vaccines will be evaluated in a chicken model for potency using serological tests samples from vaccinated birds and efficacy by challenge with antigenic drift field viruses and measuring protection by prevention of morbidity, mortality, and replication of challenge virus. Typing antisera will be produced in chickens and used in in vitro serological tests to assess antigenic variants of additional field viruses. Using the accumulated data, replacement vaccine strains will be developed.

Investigators
Swayne, David
Institution
USDA - Agricultural Research Service
Start date
2008
End date
2009
Funding Source
Agricultural Research Service
Project number
6612-32000-048-24R
Accession number
412705
Categories
Bacterial Pathogens
Sanitation and Quality Standards
Commodities
Meat, Poultry, Game