Evaluation of interventions using a novel, transdermal challenge model

Develop a precise and accurate estimation of duration of infection within the lymph nodes of cattle for various serotypes and subpopulations of Salmonella, an understanding of cellular tropism across various serotypes with and without interventions, and a rapid and well-controlled evaluation of candidate interventions designed to reduce the duration of infection within lymph nodes of cattle (particularly targeted to those subpopulations of Salmonella identified above).