Food Animal Resideu Avoidance Databank (FARAD)

The goal of the national FARAD program is to provide the most updated information and scientific tools to protect the American public by promoting the production of safe, animal-derived human food products (milk, eggs, meat, honey, etc.) that are devoid of violative or potentially unsafe chemical residues, including drugs, pesticides, environmental contaminants, natural toxins and other harmful substances.There are five specific objectives of the national FARAD program: (1) extraction and validation of data for incorporation into the system and support for FARAD's approved drug databases for publication in electronic format (VetGRAM) for internet-based delivery, including extraction of relevant data from foreign drug compendia and gFARAD partners, (2) operation of the Regional Access Centers (RAC's) at NCSU and UCD for provision of residue avoidance information, with access through the toll-free hotline and e-mail, (3) data entry, pharmacokinetic analysis, maintenance, and distribution of the FARAD files, (4) preparation of FARAD Digests for publication in the Journal of the AVMA, newsletters and FARAD fact sheets, where appropriate, for rapid dissemination of information in an ongoing crisis, and (5) continued development and validation of methods to allow extrapolative techniques to be used in providing information and advice in situations where no direct data currently exists, which is typically required for nearly all environmental contaminant exposures.The goal of the KSU component of the FARAD program is to continue development of the population physiologically based pharmacokinetic (PBPK) model framework initiated over the past two years.There are three specific objectives of the KSU component of the FARAD program: (1) to complete the ongoing project of developing a population physiologically based pharmacokinetic model (PBPK) for penicillin G in swine, cattle, and dairy cows; (2) develop a web-based graphical user interface (GUI) based on the population PBPK models developed; (3) to develop a population PBPK model for flunixin in swine and cattle based on our recently published PBPK model for flunixin that was for an average animal (i.e., without considering population variability).