FOOD ANIMAL RESIDUE AVOIDANCE DATABANK (FARAD) VMCVM COMPONENT 2021

VMCVM Regional Access Center Work Plan: During the 2021-2022project year.The regional access center at VMCVM will continue to support the essential tasks of the national FARAD program outlinedbelow, provide pharmacokinetic services to all FARAD sites, and continue developing pharmacokinetic model tools that allowFARAD responders to fully utilize published studies to avoid meat and milk violative residues in food animals. The primaryfocus areas of the VMCVM FARAD component for 2021- 2022are as follows: (1) strengthen the response team via the hiringof a veterinary pharmacology resident and graduate student (Dr. Mercer) and, in collaboration with NCSU and UC Davis,provide drug and chemical residue management expertise to veterinarians by answering telephone and internet inquiries; (2)provide training and support for new members of the response teams at each regional access center; (3) collaborate withNCSU, KSU-Olathe, UC Davis, and University of Florida, to validate (via in vivo studies) computational estimates of safe withdrawaltimes.Respond to drug and chemical residue casesThe VMCVM FARAD Regional Access Center will continue, in collaboration with NCSU and UC-Davis FARAD RegionalAccess Centers, to answer residue avoidance inquiries. This service will require the veterinary clinical pharmacologyexpertise of Dr. Jennifer Davis and a Veterinary Pharmacology Resident/PhD student, Dr. Melissa Mercer (DVM, MS). Dr.Mercer will be responsible for daily management of cases at VMCVM. This represents the newest call response center andwe have been actively answering calls since September 2018. The addition of this third call response center has facilitatedthe accuracy and timeliness of FARAD's response to as many as 70-80 cases a week. VMCVM will also continue to collaborateand contribute to writing timely FARAD Digests that focus on the management of the more common drug residue scenariosfacing food animal veterinarians. We will collaborate in outreach programs to producer groups and veterinary specialty groupssuch as AVMA, AABP, AAVPT. Dr. Davis is the current Secretary of the American Academy of Veterinary Pharmacology andTherapeutics and is uniquely positioned to ensure continued collaboration between AAVPT and FARAD. The VMCVM alsohas a long-standing relationship with the FDA Center for Veterinary Medicine, providing externship opportunities for studentsand potentially FARAD graduate students/residents. Our proximity to the FDA facilities is a great advantage in this area.Pharmacokinetic TrialsVMCVM will collaborate with NCSU and UC-Davis to obtain in vivo data to validate FARAD recommended withdrawalintervals. This will be accomplished through participation in in vivo pharmacokinetic studies in food producing animals todetermine detection times of drugs in products such as eggs, milk or tissues. VMCVM has a fully equippedPharmacology/Toxicology laboratory that will complement facilities currently in use at NCSU and UC-Davis. Animals andanimal facilities are also available through the VMCVM.