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National Agricultural Library
U.S. Department of Agriculture
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  4. Generation of an Avian Adeno-Associated Virus Vector System to Control Avian Influenza

Generation of an Avian Adeno-Associated Virus Vector System to Control Avian Influenza

Objective

The purpose of this research is to generate and evaluate a recombinant avian adeno-associated virus (AAAV) vector system which will express in vitro and in ovo recombinant chicken interferon type I (rCHIFN alpha).

More information

NON-TECHNICAL SUMMARY: Even with the creation of efficient delivery systems along with the advent of more efficacious modified live, killed and recombinant vaccines there still is a need to improve the presentation and performance of existing vaccines This project will evaluate the possibilities of utilizing the avain adeno associated virus as a vector for the delivery of chicken interferon alpha
<p>APPROACH:The evaluation of this AAAV vector system as potential immunostimulatory agent to control avian influenza will be studied as described in the following objectives. 1. Generation of a rAAAV CHIFN alpha vector system utilizing the cloned ATCC VR-865 AAAV isolate and the rCHIFN alpha (Pei, Sekellick et al. 2001; Bossis and Chiorini 2003). 2. Evaluation of in vitro and in ovo expression rCHIFN alpha. 3. Evaluation of the anti avian influenza activity of rCHIFN in vitro and in ovo.

Investigators
El-Attrache, John
Institution
Texas A&M University
Start date
2005
End date
2007
Funding Source
Nat'l. Inst. of Food and Agriculture
Project number
TEX09102
Accession number
203730
Commodities
Meat, Poultry, Game
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