GENETIC MANIPULATION OF SARA MUTANTS

Objective

Goal is to develop anti-staphylococcal agents based on inhibition of pleiotropically-acting regulators of virulence genes that prove to be effective therapies in a future increasingly filled with antibiotic resistant pathogens. This research will reveal the mechanism by which SarA regulates agr gene expression. This information is prerequisite for the rational design of inhibitors. We propose that genetic, biochemical, and structural approaches will accomplish this goal.

Investigators

Hurlburt B K

Institution

University of Arkansas

Start date

2001

End date

2004

Funding Source

Agricultural Research Service

Project number

6435-43440-040-09G

Accession number

405177