Host-Pathogen Interactions Between Salmonella and Toll-Like Receptors

Public Health Relevance: S. typhimurium is the leading cause of bacterial foodborne-disease outbreaks, and human-adapted serovars of Salmonella, such as S. typhi, cause a severe and systemic infection known as typhoid fever. This application addresses the fundamental question of how these bacterial pathogens interact with the innate immune system and how these interactions can influence the outcome of infection.