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<p>This study will undertake a rigorous desk top analysis to systematically review different lines of evidence and expert opinion on dose-response relationships for low dose exposure to genotoxic carcinogens. A statistical framework will be developed to provide robust scientific justification for establishing levels of concern for the MoE. The validity of any conclusions drawn from the analysis and statistical framework will be tested using data from a number of known human carcinogens.</p>
<p>In the UK and Europe, the general approach for assessing the risks from genotoxic carcinogens has been to reduce exposure to levels that are as low as reasonably achievable (ALARA). However, this approach does not provide a clear basis for deciding on the urgency or extent of risk management actions.</p>
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To assess the risks from genotoxic carcinogens, EU and international scientific committees are using the Margin of Exposure (MoE) approach, which compares actual exposure to No Observed Adverse Effect Levels (NOAELs) in toxicity studies. This study aims to develop a robust scientific rationale for defining levels of concern associated with given values or ranges of MoEs for genotoxic carcinogens.</P>
<p>Find more about this project and other FSA food safety-related projects at the <a href="http://www.food.gov.uk/science/research/" target="_blank">Food Standards Agency Research webpage</a>.