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National Agricultural Library
U.S. Department of Agriculture
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  4. Investigation of Direct Measurement of Phosphorylation of the Active Site of Esterases as Sensitive Biomarkers of Organophosphate Exposure

Investigation of Direct Measurement of Phosphorylation of the Active Site of Esterases as Sensitive Biomarkers of Organophosphate Exposure

Objective

This research project will evaluate biomarkers at the low levels of pesticide residues to which consumers are exposed to in the diet.

<p>This project will investigate interaction of organophosphates with esterases in order to develop a highly sensitive biomarker of combined exposure.

<p>The biomarker will then be evaluated in individuals who are exposed to low levels of pesticide mixtures.

More information

In its report on Risk Assessment of Mixtures of Pesticides and Similar Substances, the Committee on Toxicity of Chemicals in Food Consumer Products and the Environment (COT) highlighted the requirement for tools to investigate exposure to, and possible interactive effects of, mixtures of pesticides.

<p>These tools will support risk assessment of chronic exposure to mixtures of pesticides at low levels.

<p>Find more about this project and other FSA food safety-related projects at the <a href="http://www.food.gov.uk/science/research/&quot; target="_blank">Food Standards Agency Research webpage</a>.

Institution
University of Newcastle upon Tyne
Start date
2005
End date
2007
Funding Source
Food Standards Agency
Project number
T10010
Categories
Pesticide Residues