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National Agricultural Library
U.S. Department of Agriculture
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  4. Mechanism of Tumorigenic Pyrrolizidine Alkaloids and Development of LC/ES/MS/MS Methodology for Detection and Quantification of Pyrrolizidine Alkaloids

Mechanism of Tumorigenic Pyrrolizidine Alkaloids and Development of LC/ES/MS/MS Methodology for Detection and Quantification of Pyrrolizidine Alkaloids

Objective

<p>
<ol>
<li>Validate the proposed mechanism by which pyrrolizidine alkaloids induce tumors in rodents.</li>
<li>Develop an LC/ES/MS/MS method for detection and quantification of DHP-derived DNA adducts in rodents.</li>
<li>Develop an LC/ES/MS/MS method for detection and quantification of genotoxic pyrrolizidine alkaloids in herbal plants and herbal dietary supplements.</li>
<li>Develop an LC/ES/MS/MS method for detection and quantification of DHP-derived hemoglobin adducts in rodents.</li></ol></p>

More information

Responsible Division: Biochemical Toxicology

Investigators
Fu, Peter
Institution
DHHS/FDA - National Center for Toxicological Research
Funding Source
Nat'l. Center For Toxicological Research
Project number
E0728901
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