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National Agricultural Library
U.S. Department of Agriculture
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  4. MECHANISMS AND BIOMARKERS FOR DEOXYNIVALENOL-INDUCED GROWTH RETARDATION

MECHANISMS AND BIOMARKERS FOR DEOXYNIVALENOL-INDUCED GROWTH RETARDATION

Objective

To improve understanding of mechanisms, biomarkers, and thresholds for trichothecene-induced health effects for application to risk assessment. Test the hypothesis that DON-induced growth retardation results from DON-induced cytokine-mediated SOCS-3 upregulation, which inhibits hepatic GH signaling, leading to reductions of growth factor(s) and weight gain.

Investigators
Fravel D R
Institution
Michigan State University
Start date
2009
End date
2014
Funding Source
Agricultural Research Service
Project number
0500-00053-002-96G
Accession number
416939
Categories
Risk Assessment, Management, and Communication
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