Mechanisms for Control of Vibrio Cholerae Virulence

Public Health Relevance: Cholera is a major public health problem in many developing countries and areas suffering from the effects of war or natural disaster, with an estimated 5,000,000 new cases each year. The goal of this proposal is to understand how V. cholerae virulence factor expression is controlled by effectors in the human small intestine and the major regulatory protein ToxT. Achieving this new level of understanding could identify new therapeutic targets and/or targets for vaccine development.