Mechanisms of Immunity to Food-Poisoning and Vaccine Serotypes of Salmonella in Chickens

Food-poisoning from certain Salmonella serotypes found in chicken and eggs continue to rise each year, despite more stringent procedures as well as use of antibiotics and killed vaccines. Live vaccines offer the promise of simple, effective and sustainable biological control. However, existing candidate live vaccines do not provide the protection that results from recovery from infection. <P>
In order to gain the fundamental knowledge necessary to develop effective live vaccines in a rational manner, we propose to establish a substantial and long-term collaboration between the University of Cambridge and the Institute for Animal Health to thoroughly examine the mechanisms of immunity to both food-poisoning and potential vaccine serotypes of Salmonella in chickens. (Joint with grant BFP11367).