This project will characterize the whole blood response of healthy subjects to LGG using a select panel of cytokine and chemokine markers detected by real time PCR, and a more robust evaluation of transcriptomic changes detected prior to during and after feeding of LGG. Associations will be developed with the levels of LGG, Bifidobacterium and Lactobacillus spp. in the feces and naso-pharynx. The cooperator is interested in detecting LGG and evaluating the clinical effects in healthy adults fed LGG as part of a Phase I study to demonstrate safety strain.
OPEN LABEL STUDY TO EVALUATE THE SAFETY OF LACTOBACILLUS RHAMNOSUS GG ATCC 53103 IN HEALTHY VOLUNTEERS
Objective
Investigators
Solano-Aguilar, Gloria
Institution
USDA - Agricultural Research Service
Start date
2010
End date
2014
Funding Source
Project number
1235-51000-055-11R
Accession number
420658