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National Agricultural Library
U.S. Department of Agriculture
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  4. PH/GBA3-Dependent Stability of D3G's Glycosidic Bond and the Potential Risk to Human Health

PH/GBA3-Dependent Stability of D3G's Glycosidic Bond and the Potential Risk to Human Health

Objective

(1) Develop appropriate approaches (e.g. HPLC, LC/MS/MS, and other pharmacology/molecular biology techniques) to determine the levels of DON and D3G in agricultural products and to determine the rate of D3G deconjugation and relative concentration of D3G vs. DON during human digestion and metabolism, (2) Determine the toxic effects and mechanisms of D3G and DON (and other related metabolites) in humans.

Investigators
Costa, Jose
Institution
North Dakota State University
Start date
2013
End date
2015
Funding Source
Agricultural Research Service
Project number
0500-00053-003-59G
Accession number
425278
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