To determine the necessary parameters for a biologically based dose-response model to predict neurotoxic adverse effects following exposure to cholinesterase-inhibiting pesticides. Such information would improve the ability of risk assessments to evaluate toxicological data for potential human health risk and address a specific need identified by the Neurotoxicity Risk Assessment Guidelines.
FY 2000 Accomplishments: This EPA/NCTR IAG was established, postdoctoral support recruited and hired, and essential equipment purchased.
FY 2001 Plans:Develop a preliminary biologically based dose-response model for foodborne pesticides.