Safety Assessment RP29 Pediococcus Acidilactici CNCM I-4622

An application was submitted to the Food Standards Agency in January 2021 from Lallemand SAS (on behalf of Danstar Ferment AG, Switzerland), France (“the applicant”) for the authorisation of an additive containing Pediococcus acidilactici CNCM I-4622, under the category of ‘technological’ additives, functional groups ‘hygiene condition enhancers’ and ‘acidity regulators’. The additive contains freeze-dried viable cells of Pediococcus acidilactici, a technological additive and a feed material that is proposed to be supplied at a minimum of 1x109 colony forming units (CFU)/kg of complete feed at 12% moisture for all animal species and categories. It aims to reduce the development of coliform bacteria through the reduction of pH and increasing lactic acid concentration in feed. To support the Food Standards Agency (FSA) and Food Standards Scotland (FSS) in evaluating the dossier, the Animal Feed and Feed Additives Joint Group (AFFAJEG) and the Advisory Committee on Animal Feedingstuffs (ACAF) were asked to review the dossier and the supplementary information from the applicant. Upon evaluation of the dossier, ACAF concluded that the additive is compatible with a limited number of commercially available coccidiostats. Pediococcus acidilactici CNCM I-4622 is a qualified presumption of safety (QPS) organism, therefore, no data on safety for the target species, consumers or the environment was analysed. ACAF concluded that the additive should be considered a respiratory sensitiser. The ACAF evaluated efficacy data from five in-vitro studies and concluded that the additive can be considered efficacious as an acidity regulator and a hygiene condition enhancer within the first 24 h after administration of the proposed dose of 1x109 CFU/kg of complete feed at 12% moisture. The views of AFFAJEG and ACAF have been taken into account in the safety assessment which represents the opinion of the FSA and FSS.