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Explore and develop opportunities for control based on data identifying and characterizing routes of infection of Salmonella in the lymph nodes of cattle. Salmonella vaccine and chlorate will be evaluated to determine effectiveness in eliminating Salmonella from the lymph nodes following oral and dermal inoculation of dairy cattle.
Approach:
Three studies will be conducted using dairy calves purchased and transported to our laboratory in College Station, TX. The first study will examine the duration and distribution of infection of Salmonella in several lymph nodes in calves receiving an SRP Salmonella vaccine. The second study will examine routes of exposure (oral or dermal) on Salmonella uptake and distribution by the lymph nodes. The final study will examine the effectiveness of sodium chlorate in eliminating Salmonella from the lymph nodes of previously infected calves.